FACULTY OF ENGINEERING
Department of Genetics and Bioengineering
GBE 206 | Course Introduction and Application Information
| Course Name |
Genetics
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 206
|
Fall
|
2
|
2
|
3
|
5
|
| Prerequisites |
None
|
|||||
| Course Language |
English
|
|||||
| Course Type |
Required
|
|||||
| Course Level |
First Cycle
|
|||||
| Mode of Delivery | - | |||||
| Teaching Methods and Techniques of the Course | - | |||||
| Course Coordinator | ||||||
| Course Lecturer(s) | ||||||
| Assistant(s) | ||||||
| Course Objectives | The aim of this course is to teach the molecular structure and function of the genome, along with fundamental insights into genetic variants and their consequences in the cell and population. It is also aimed to teach the methodology in order to link phenotype to genotype and determine pathological gene mechanisms. |
| Learning Outcomes |
The students who succeeded in this course;
|
| Course Description | The mechanisms controlling the expression of genetic information and the patterns inheriting this vital information at cellular and population levels will be covered. There will be detailed information on the events occurring whilst reading the genetic code as well as the genetic/epigenetic parameters necessary revealing this code. How the impairments of such mechanisms could cause diseases will be discussed with examples. Additionally, theoretical background will be given on the techniques used to measure such parameters together with discussions on their ethical/legal aspects. |
|
|
Core Courses |
X
|
| Major Area Courses | ||
| Supportive Courses | ||
| Media and Management Skills Courses | ||
| Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Related Preparation |
| 1 | The content of the genome | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-9. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012. |
| 2 | Circuit elements of a gene | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012. |
| 3 | Chromosome architecture | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-2. • Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739. |
| 4 | Classical gene control mechanisms | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases, Decker and Hinton, Annual Reviews, 2013. |
| 5 | Epigenetic gene control mechanisms: Histone modifications | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016. |
| 6 | Epigenetic gene control mechanisms: Histone modifications | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016. |
| 7 | Epigenetic gene control mechanisms: DNA methylation | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Principles of DNA methylation and their implications for biology and medicine, Dor and Cedar, Lancet, 2018. |
| 8 | Review and Midterm Exam | |
| 9 | Post transcriptional gene control mechanisms | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Molecular mechanisms of RNA interference, Wilson and Doudna. Annual Reviews, vol. 42:217-239 |
| 10 | Human Genetic variation | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-11. |
| 11 | Chromosomal abnormalities and structural variants | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-15. |
| 12 | Human Population Genetics | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-12. |
| 13 | Connecting phenotypes to genotypes | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-16. |
| 14 | Mapping and identifying genes causing disease | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-17. |
| 15 | Review of the semester | |
| 16 | Final Exam |
| Course Notes/Textbooks | Human Molecular Genetics. Strachan and Read, Garland Science, 2018. ISBN: 0815345895 |
| Suggested Readings/Materials | • Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739.
• Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012.
• Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases, Decker and Hinton, Annual Reviews, 2013.
• Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016.
• Principles of DNA methylation and their implications for biology and medicine, Dor and Cedar, Lancet, 2018.Molecular mechanisms of RNA interference, Wilson and Doudna. Annual Reviews, vol. 42:217-239
|
EVALUATION SYSTEM
| Semester Activities | Number | Weigthing |
| Participation | ||
| Laboratory / Application | ||
| Field Work | ||
| Quizzes / Studio Critiques | ||
| Portfolio | ||
| Homework / Assignments |
1
|
30
|
| Presentation / Jury | ||
| Project | ||
| Seminar / Workshop | ||
| Oral Exams | ||
| Midterm |
1
|
30
|
| Final Exam |
1
|
40
|
| Total |
| Weighting of Semester Activities on the Final Grade |
2
|
60
|
| Weighting of End-of-Semester Activities on the Final Grade |
1
|
40
|
| Total |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
2
|
32
|
| Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
2
|
32
|
| Study Hours Out of Class |
14
|
2
|
28
|
| Field Work |
0
|
||
| Quizzes / Studio Critiques |
5
|
0
|
|
| Portfolio |
0
|
||
| Homework / Assignments |
1
|
10
|
10
|
| Presentation / Jury |
0
|
||
| Project |
0
|
||
| Seminar / Workshop |
0
|
||
| Oral Exam |
0
|
||
| Midterms |
1
|
18
|
18
|
| Final Exam |
1
|
23
|
23
|
| Total |
143
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
|
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
|
1
|
2
|
3
|
4
|
5
|
||
| 1 | To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems. |
X | ||||
| 2 | To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. |
X | ||||
| 3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. |
|||||
| 4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively. |
|||||
| 5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics. |
X | ||||
| 6 | To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually. |
|||||
| 7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. |
|||||
| 8 | To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions. |
|||||
| 9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications. |
X | ||||
| 10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. |
|||||
| 11 | To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language. |
|||||
| 12 | To be able to speak a second foreign language at a medium level of fluency efficiently. |
|||||
| 13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering. |
|||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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