FACULTY OF ENGINEERING
Department of Genetics and Bioengineering
GBE 330 | Course Introduction and Application Information
| Course Name |
Nobel Prize-Winning Studies
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Code
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Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 330
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Fall/Spring
|
3
|
0
|
3
|
5
|
| Prerequisites |
None
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| Course Language |
English
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| Course Type |
Elective
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| Course Level |
First Cycle
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| Mode of Delivery | - | |||||
| Teaching Methods and Techniques of the Course | DiscussionQ&ALecture / Presentation | |||||
| Course Coordinator | ||||||
| Course Lecturer(s) | ||||||
| Assistant(s) | - | |||||
| Course Objectives | The Nobel Prize is an international award administered by the Nobel Foundation in Stockholm, Sweden to “those who, during the preceding year, shall have conferred the greatest benefit on mankind”. By selecting Nobel prize-winning contributions in Genetics and Bioengineering-related areas, this course will focus on exploring the history behind some of the greatest achievements in science. We will further examine the lives of the laureates, the science behind the discovery and the impact of the prize on society. |
| Learning Outcomes |
The students who succeeded in this course;
|
| Course Description | This course covers the scientific description and contribution of Nobel Prize-winning studies in the field of Genetics and Bioengineering. |
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Core Courses | |
| Major Area Courses |
X
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| Supportive Courses | ||
| Media and Management Skills Courses | ||
| Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Related Preparation |
| 1 | Introduction to Nobel Prize | www.nobelprize.org |
| 2 | “Genetic regulation of organ development and programmed cell death” - Sydney Brenner, H. Robert Horvitz and John E. Sulston | Sydney Brenner. Nature’s gift to science. Nobel Lecture, December 8, 2002. https://www.nobelprize.org/uploads/2018/06/brenner-lecture.pdf (28/04/2019 - 14:02) H. Robert Horvitz. Worms, life and death. Nobel Lecture, December 8, 2002 https://www.nobelprize.org/uploads/2018/06/horvitz-lecture.pdf (28/04/2019 - 14:02) John E. Sulston. C. elegans: The cell Lineage and beyond. Nobel Lecture, December 8, 2002. https://www.nobelprize.org/uploads/2018/06/sulston-lecture.pdf (28/04/2019 - 14:02) |
| 3 | “Discovery and development of the green fluorescent protein” - Osamu Shimomura, Martin Chalfie and Roger Y. Tsie | Osamu Shimomura. Discovery of green fluorescent protein, GFP. Nobel Lecture, December 8, 2008. https://www.nobelprize.org/uploads/2018/06/shimomura_lecture.pdf (28/04/2019 - 14:02) Roger Y. Tsien. Constructing and exploiting the fluorescent protein paintbox. Nobel Lecture, December 8, 2008. https://www.nobelprize.org/uploads/2018/06/tsien_lecture.pdf (28/04/2019 - 14:02) |
| 4 | “The specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies” - Niels K. Jerne, Georges J.F. Köhler and César Milstein | Niels K. Jerne. The generative grammar of, the immune system. Nobel lecture, 8 December 1984. https://www.nobelprize.org/uploads/2018/06/jerne-lecture.pdf (28/04/2019 - 14:02) Georges Köhler. Derivation and diversification of monoclonal antibodies. Nobel lecture, 8 December, 1984. https://www.nobelprize.org/uploads/2018/06/kohler-lecture.pdf (28/04/2019 - 14:02)César Milstein. From the structure of antibodies to the diversification of the immune response. Nobel lecture, 8 December, 1984. https://www.nobelprize.org/uploads/2018/06/milstein-lecture.pdf (28/04/2019 - 14:02) |
| 5 | “Odorant receptors and the organization of the olfactory system” - Richard Axel and Linda B. Buck | Richard Axel. Scents and sensibility: a molecular logic of olfactory perception. Nobel Lecture, December 8, 2004. https://www.nobelprize.org/uploads/2018/06/axel-lecture.pdf (28/04/2019 - 14:02) Linda B. Buck. Unraveling the sense of smell. Nobel Lecture, December 8, 2004. https://www.nobelprize.org/uploads/2018/06/buck-lecture.pdf (28/04/2019 - 14:02) |
| 6 | “The biochemistry of nucleic acids, with particular regard to recombinant-DNA” - Paul Berg “The determination of base sequences in nucleic acids” - Walter Gilbert and Frederick Sanger | Nicole Kresge, Robert D. Simoni and Robert L. Hill Amino Acyl Ribonucleic Acid Formation and Recombinant DNA Technology: the Work of Paul Berg. The journal of biological chemistry Vol. 280, No. 45, Issue of November 11, p. e42, 2005. Shendure J, Balasubramanian S, Church GM, Gilbert W, Rogers J, Schloss JA, Waterston RH. DNA sequencing at 40: past, present and future. Nature. 2017 Oct 19;550(7676):345-353. doi: 10.1038/nature24286. Epub 2017 Oct 11. |
| 7 | “Discovery of cancer therapy by inhibition of negative immune regulation” - James P. Allison and Tasuku Honjo | C. I. Edvard Smith, Rikard Holmdahl, Olle Kämpe & Klas Kärre. Discovery of cancer therapy by inhibition of negative immune regulation. Members of the Nobel Committee and Members of the Nobel Assembly. Karolinska Institutet, Stockholm, September 30, 2018. https://www.nobelprize.org/uploads/2018/10/advanced-medicineprize2018.pdf (28/04/2019 - 14:02) |
| 8 | “The discovery that mature cells can be reprogrammed to become pluripotent” - Sir John B. Gurdon and Shinya Yamanaka | Sir John B. Gurdon. The Egg and the Nucleus: A Battle for Supremacy. Nobel Lecture, December 7, 2013. https://www.nobelprize.org/uploads/2018/06/gurdon-lecture.pdf (28/04/2019 - 14:02) Shinya Yamanaka. The Winding Road to Pluripotency. Nobel Lecture, December 7, 2012. https://www.nobelprize.org/uploads/2018/06/yamanaka-lecture.pdf (28/04/2019 - 14:02) |
| 9 | “Discoveries of mechanisms for autophagy” - Yoshinori Ohsumi | Yoshinori Ohsumi. Molecular Mechanisms of Autophagy in Yeast. Nobel Lecture, December 7, 2016. https://www.nobelprize.org/uploads/2018/06/ohsumi-lecture.pdf (28/04/2019 - 14:02) |
| 10 | “Discoveries of molecular mechanisms controlling the circadian rhythm” - Jeffrey C. Hall, Michael Rosbash and Michael W. Young | Huang RC. The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine. Biomed J. 2018 Feb;41(1):5-8. doi: 10.1016/j.bj.2018.02.003. Epub 2018 Mar 29. |
| 11 | ”Invention of the polymerase chain reaction (PCR) method” - Kary B. Mullis | Kary B. Mullis. The Polymerase Chain Reaction. Nobel Lecture, December 8, 1993. https://www.nobelprize.org/prizes/chemistry/1993/mullis/lecture/ (28/04/2019 - 14:02) |
| 12 | Second Midterm Exam | |
| 13 | “Discoveries of cells that constitute a positioning system in the brain” - John O’Keefe, May-Britt Moser and Edvard I. Moser | John O’Keefe. Spatial Cells in the Hippocampal Formation. Nobel Lecture, 7 December 2014. https://www.nobelprize.org/uploads/2018/06/okeefe-lecture.pdf (28/04/2019 - 14:02) May-Britt Moser. Grid Cells, Place Cells and Memory. Nobel Lecture, 7 December 2014. https://www.nobelprize.org/uploads/2018/06/may-britt-moser-lecture.pdf (28/04/2019 - 14:02) Edvard I. Moser. Grid Cells and the Entorhinal Map of Space. Nobel Lecture, 7 December 2014. https://www.nobelprize.org/uploads/2018/06/edvard-moser-lecture.pdf (28/04/2019 - 14:02) |
| 14 | “Discovery of RNA interference – gene silencing by double-stranded RNA” - Andrew Z. Fire and Craig C. Mello | Andrew Z. Fire. Gene silencing by double stranded RNA. Nobel Lecture, December 8, 2006. https://www.nobelprize.org/uploads/2018/06/fire_lecture.pdf (28/04/2019 - 14:02) Craig C. Mello. Return to the RNAi world: rethinking gene expression and evolution. Nobel Lecture, December 8, 2006. https://www.nobelprize.org/uploads/2018/06/mello_lecture.pdf (28/04/2019 - 14:02) |
| 15 | “Development of a method for genome editing." Emmanuelle Charpentier Jennifer A. Doudna | Emmanuelle Charpentier and Jennifer A. Doudna, Genetic scissors: a tool for rewriting the code of life. https://www.nobelprize.org/uploads/2020/10/popular-chemistryprize2020.pdf (09/06/2012 - 17:00) |
| 16 | Final Exam |
| Course Notes/Textbooks | Francis Leroy. A Century of Nobel Prize Recipients: Chemistry, Physics, and Medicine (Neurological Disease & Therapy) 1st Edition. CRC Press; 1 edition (March 13, 2003). ISBN: 978-0824708764. |
| Suggested Readings/Materials |
EVALUATION SYSTEM
| Semester Activities | Number | Weigthing |
| Participation | ||
| Laboratory / Application | ||
| Field Work | ||
| Quizzes / Studio Critiques | ||
| Portfolio | ||
| Homework / Assignments |
1
|
25
|
| Presentation / Jury |
1
|
25
|
| Project | ||
| Seminar / Workshop | ||
| Oral Exams | ||
| Midterm |
1
|
20
|
| Final Exam |
1
|
30
|
| Total |
| Weighting of Semester Activities on the Final Grade |
3
|
70
|
| Weighting of End-of-Semester Activities on the Final Grade |
1
|
30
|
| Total |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
| Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
| Study Hours Out of Class |
16
|
2
|
32
|
| Field Work |
0
|
||
| Quizzes / Studio Critiques |
0
|
||
| Portfolio |
0
|
||
| Homework / Assignments |
1
|
10
|
10
|
| Presentation / Jury |
1
|
20
|
20
|
| Project |
0
|
||
| Seminar / Workshop |
0
|
||
| Oral Exam |
0
|
||
| Midterms |
1
|
20
|
20
|
| Final Exam |
1
|
20
|
20
|
| Total |
150
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
|
#
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Program Competencies/Outcomes |
* Contribution Level
|
||||
|
1
|
2
|
3
|
4
|
5
|
||
| 1 | To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems. |
X | ||||
| 2 | To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. |
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| 3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. |
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| 4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively. |
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| 5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics. |
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| 6 | To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually. |
X | ||||
| 7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. |
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| 8 | To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions. |
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| 9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications. |
X | ||||
| 10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. |
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| 11 | To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language. |
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| 12 | To be able to speak a second foreign language at a medium level of fluency efficiently. |
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| 13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering. |
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*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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