FACULTY OF ENGINEERING
Department of Genetics and Bioengineering
GBE 340 | Course Introduction and Application Information
| Course Name |
Cell Death Mechanisms
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 340
|
Fall/Spring
|
3
|
0
|
3
|
5
|
| Prerequisites |
None
|
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| Course Language |
English
|
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| Course Type |
Elective
|
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| Course Level |
First Cycle
|
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| Mode of Delivery | - | |||||
| Teaching Methods and Techniques of the Course | DiscussionGroup WorkQ&ALecture / Presentation | |||||
| Course Coordinator | ||||||
| Course Lecturer(s) | ||||||
| Assistant(s) | - | |||||
| Course Objectives | This course will focus on understanding the basics of conventional as well as unconventional cell death mechanisms and their roles in development, physiology and pathology. It will cover a broad range of topics in cell death field including apoptosis, autophagy, necrosis, necroptosis, lysosome-dependent cell death, entosis, anoikis, ferroptosis, pyroptosis, anastasis, mitotic death and immunogenic cell death. |
| Learning Outcomes |
The students who succeeded in this course;
|
| Course Description | This course covers the description of molecular mechanisms of cell death including apoptosis, autophagy, necrosis, necroptosis, lysosome-dependent cell death, entosis, anoikis, ferroptosis, pyroptosis, anastasis, mitotic death and immunogenic cell death. |
|
|
Core Courses | |
| Major Area Courses |
X
|
|
| Supportive Courses | ||
| Media and Management Skills Courses | ||
| Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Related Preparation |
| 1 | Introduction to cell death modalities | Alberts et.al. 6th Edition. Chapter 18. |
| 2 | Non-programmed cell death: Necrosis | Alberts et.al. 6th Edition. Chapter 18. |
| 3 | Programmed apoptotic cell death: Apoptotic Cell Death and Anoikis | Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. |
| 4 | Intrinsic and Extrinsic Apoptotic Cell Death | Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. |
| 5 | Apoptotic Cell Death Detection Methods | Galluzzi, L et al. “Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012” Cell death and differentiation vol. 19,1 (2011): 107-20. |
| 6 | Programmed non-apoptotic cell death: Vacuole based | |
| 7 | Programmed non-apoptotic cell death: Mitochondria and iron based | Kroemer, G et al. “Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009” Cell death and differentiation vol. 16,1 (2008): 3-11. |
| 8 | Mid-Term Exam | Kroemer, G et al. “Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009” Cell death and differentiation vol. 16,1 (2008): 3-11. |
| 9 | Programmed non-apoptotic cell death: Vacuole based: Immunogenic cell death and others | Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. |
| 10 | Programmed cell death in prokaryotes | Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. |
| 11 | Clinical aspects of cell death | Douglas R Green. Means to an End: Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press. 2017. Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. |
| 12 | Non-lethal processes such as anastasis, mitotic destruction and cellular senescence | |
| 13 | Cell-in-cell death (entosis, cannibalism and imperitosis) | Galluzzi L, Buqué A, Kepp O, Zitvogel L, Kroemer G. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 2017 Feb;17(2):97-111. doi: 10.1038/nri.2016.107. Epub 2016 Oct 17. |
| 14 | Semester review | |
| 15 | Semester review | |
| 16 | Final exam |
| Course Notes/Textbooks | Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter. Molecular Biology of the Cell. Sixth Edition. Chapter 18 – Cell Death. Garland Science, 2014: New York and Abingdon, UK. Douglas R Green. Means to an End: Apoptosis and Other Cell Death Mechanisms. Cold Spring Harbor Laboratory Press. 2017. |
| Suggested Readings/Materials | Galluzzi, Lorenzo et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018” Cell death and differentiation vol. 25,3 (2018): 486-541. Galluzzi, L et al. “Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012” Cell death and differentiation vol. 19,1 (2011): 107-20. Kroemer, G et al. “Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009” Cell death and differentiation vol. 16,1 (2008): 3-11. Sun G and Montell DJ. Q&A: Cellular near death experiences-what is anastasis? BMC Biol. 2017 Oct 24;15(1):92. doi: 10.1186/s12915-017-0441-z. |
EVALUATION SYSTEM
| Semester Activities | Number | Weigthing |
| Participation | ||
| Laboratory / Application | ||
| Field Work | ||
| Quizzes / Studio Critiques | ||
| Portfolio | ||
| Homework / Assignments |
1
|
15
|
| Presentation / Jury |
1
|
15
|
| Project | ||
| Seminar / Workshop | ||
| Oral Exams | ||
| Midterm |
1
|
30
|
| Final Exam |
1
|
40
|
| Total |
| Weighting of Semester Activities on the Final Grade |
3
|
70
|
| Weighting of End-of-Semester Activities on the Final Grade |
1
|
30
|
| Total |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
| Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
| Study Hours Out of Class |
16
|
2
|
32
|
| Field Work |
0
|
||
| Quizzes / Studio Critiques |
0
|
||
| Portfolio |
0
|
||
| Homework / Assignments |
1
|
10
|
10
|
| Presentation / Jury |
1
|
20
|
20
|
| Project |
0
|
||
| Seminar / Workshop |
0
|
||
| Oral Exam |
0
|
||
| Midterms |
1
|
20
|
20
|
| Final Exam |
1
|
20
|
20
|
| Total |
150
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
|
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
|
1
|
2
|
3
|
4
|
5
|
||
| 1 | To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems. |
X | ||||
| 2 | To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. |
X | ||||
| 3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. |
|||||
| 4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively. |
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| 5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics. |
|||||
| 6 | To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually. |
X | ||||
| 7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. |
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| 8 | To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions. |
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| 9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications. |
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| 10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. |
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| 11 | To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language. |
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| 12 | To be able to speak a second foreign language at a medium level of fluency efficiently. |
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| 13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering. |
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*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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