FACULTY OF ENGINEERING

Department of Genetics and Bioengineering

GBE 360 | Course Introduction and Application Information

Course Name
Cell Signaling
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
GBE 360
Fall/Spring
3
0
3
5

Prerequisites
None
Course Language
English
Course Type
Elective
Course Level
First Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course Discussion
Group Work
Q&A
Lecture / Presentation
Course Coordinator
Course Lecturer(s)
Assistant(s) -
Course Objectives The course aims to give participants a basic knowledge of mechanisms of signal transduction and the significance of signal transduction in physiology and pathophysiology.
Learning Outcomes The students who succeeded in this course;
  • Describe what signal transduction means and its biological principles;
  • Understand and compare the vast and increasing diversity of signaling mechanisms described to date: receptors, ligands, second messengers, adaptors, post-translational modifications, crosstalk;
  • Explain the importance of signal transduction in development, health and disease;
  • Discuss signal transduction literature;
  • Formulate questions and hypothesize new solutions that will challenge the current paradigms in cell signaling.
Course Description Basic principles of cell signaling. Characterization of signalling components: signalling molecules, receptors, second messengers, effectors, signalling complexes. Basic classification and characterization of membrane receptors. Intracellular/nuclear receptors. Major signalling pathways.

 



Course Category

Core Courses
Major Area Courses
X
Supportive Courses
Media and Management Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Related Preparation
1 Signal Transduction Mechanisms: Signals and Sensors Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 1-1,2
2 Signal Transduction Mechanisms: Second Messengers Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 1-3
3 Signaling Pathways: G-Protein Coupled Receptor Signaling Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2
4 Signaling Pathways: Receptor and Non-Receptor Tyrosine Kinases Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2
5 Signaling Pathways: Serine/Threonin Kinase Coupled Receptors Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2
6 Signaling Pathways: Mitogen Activated Protein Kinases Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2
7 Signaling Pathways: Phosphatidylinositol Mediated Signaling Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2
8 Midterm
9 Growth Factor Signaling Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
10 Cellular Death Signaling Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
11 DNA Damage Response Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
12 Heat Shock and ER Stress Response Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
13 Metabolism and Signaling Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
14 Signal Tranduction in Health and Disease Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3
15 Semester Review
16 Final Exam

 

Course Notes/Textbooks

Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley, Tony Thunter, Richard Sever and Jeremy Thorner.

Molecular Biology of the Cell, by Alberts B, et al. Garland Science ISBN-13: 978-0815345244

Suggested Readings/Materials

• Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley, Tony Thunter, Richard Sever and Jeremy Thorner.

• Cellular Signaling Processing. 2008. Garland Science. Friedrich Marks, Ursula Klingmuller and Karin Muller-Decker.

• Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss.

• Signal Transduction. 2015. Academic Press. Bastien D. Gomperts, Ijsbrand M. Kramer and Peter E. R. Tatham.

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
1
10
Portfolio
Homework / Assignments
1
10
Presentation / Jury
1
25
Project
Seminar / Workshop
Oral Exams
Midterm
1
25
Final Exam
1
30
Total

Weighting of Semester Activities on the Final Grade
3
70
Weighting of End-of-Semester Activities on the Final Grade
1
30
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Theoretical Course Hours
(Including exam week: 16 x total hours)
16
3
48
Laboratory / Application Hours
(Including exam week: '.16.' x total hours)
16
0
Study Hours Out of Class
14
2
28
Field Work
0
Quizzes / Studio Critiques
1
0
Portfolio
0
Homework / Assignments
1
12
12
Presentation / Jury
1
20
20
Project
0
Seminar / Workshop
0
Oral Exam
0
Midterms
1
17
17
Final Exam
1
25
25
    Total
150

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems.

X
2

To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose.

X
3

To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose.

4

To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively.

5

To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics.

6

To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually.

X
7

To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions.

8

To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions.

9

To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications.

10

To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development.

11

To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language.

12

To be able to speak a second foreign language at a medium level of fluency efficiently.

13

To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering.

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest

 


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