FACULTY OF ENGINEERING
Department of Genetics and Bioengineering
GBE 360 | Course Introduction and Application Information
Course Name |
Cell Signaling
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
GBE 360
|
Fall/Spring
|
3
|
0
|
3
|
5
|
Prerequisites |
None
|
|||||
Course Language |
English
|
|||||
Course Type |
Elective
|
|||||
Course Level |
First Cycle
|
|||||
Mode of Delivery | - | |||||
Teaching Methods and Techniques of the Course | DiscussionGroup WorkQ&ALecture / Presentation | |||||
Course Coordinator | ||||||
Course Lecturer(s) | ||||||
Assistant(s) | - |
Course Objectives | The course aims to give participants a basic knowledge of mechanisms of signal transduction and the significance of signal transduction in physiology and pathophysiology. |
Learning Outcomes |
The students who succeeded in this course;
|
Course Description | Basic principles of cell signaling. Characterization of signalling components: signalling molecules, receptors, second messengers, effectors, signalling complexes. Basic classification and characterization of membrane receptors. Intracellular/nuclear receptors. Major signalling pathways. |
|
Core Courses | |
Major Area Courses |
X
|
|
Supportive Courses | ||
Media and Management Skills Courses | ||
Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
Week | Subjects | Related Preparation |
1 | Signal Transduction Mechanisms: Signals and Sensors | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 1-1,2 |
2 | Signal Transduction Mechanisms: Second Messengers | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 1-3 |
3 | Signaling Pathways: G-Protein Coupled Receptor Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2 |
4 | Signaling Pathways: Receptor and Non-Receptor Tyrosine Kinases | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2 |
5 | Signaling Pathways: Serine/Threonin Kinase Coupled Receptors | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2 |
6 | Signaling Pathways: Mitogen Activated Protein Kinases | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2 |
7 | Signaling Pathways: Phosphatidylinositol Mediated Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 2 |
8 | Midterm | |
9 | Growth Factor Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
10 | Cellular Death Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
11 | DNA Damage Response | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
12 | Heat Shock and ER Stress Response | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
13 | Metabolism and Signaling | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
14 | Signal Tranduction in Health and Disease | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Section 3 |
15 | Semester Review | |
16 | Final Exam |
Course Notes/Textbooks | Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley, Tony Thunter, Richard Sever and Jeremy Thorner. Molecular Biology of the Cell, by Alberts B, et al. Garland Science ISBN-13: 978-0815345244 |
Suggested Readings/Materials | • Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley, Tony Thunter, Richard Sever and Jeremy Thorner. • Cellular Signaling Processing. 2008. Garland Science. Friedrich Marks, Ursula Klingmuller and Karin Muller-Decker. • Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss. • Signal Transduction. 2015. Academic Press. Bastien D. Gomperts, Ijsbrand M. Kramer and Peter E. R. Tatham. |
EVALUATION SYSTEM
Semester Activities | Number | Weigthing |
Participation | ||
Laboratory / Application | ||
Field Work | ||
Quizzes / Studio Critiques |
1
|
10
|
Portfolio | ||
Homework / Assignments |
1
|
10
|
Presentation / Jury |
1
|
25
|
Project | ||
Seminar / Workshop | ||
Oral Exams | ||
Midterm |
1
|
25
|
Final Exam |
1
|
30
|
Total |
Weighting of Semester Activities on the Final Grade |
3
|
70
|
Weighting of End-of-Semester Activities on the Final Grade |
1
|
30
|
Total |
ECTS / WORKLOAD TABLE
Semester Activities | Number | Duration (Hours) | Workload |
---|---|---|---|
Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
Study Hours Out of Class |
14
|
2
|
28
|
Field Work |
0
|
||
Quizzes / Studio Critiques |
1
|
0
|
|
Portfolio |
0
|
||
Homework / Assignments |
1
|
12
|
12
|
Presentation / Jury |
1
|
20
|
20
|
Project |
0
|
||
Seminar / Workshop |
0
|
||
Oral Exam |
0
|
||
Midterms |
1
|
17
|
17
|
Final Exam |
1
|
25
|
25
|
Total |
150
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
1
|
2
|
3
|
4
|
5
|
||
1 | To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems. |
X | ||||
2 | To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. |
X | ||||
3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. |
|||||
4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively. |
|||||
5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics. |
|||||
6 | To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually. |
X | ||||
7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. |
|||||
8 | To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions. |
|||||
9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications. |
|||||
10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. |
|||||
11 | To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language. |
|||||
12 | To be able to speak a second foreign language at a medium level of fluency efficiently. |
|||||
13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering. |
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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