FACULTY OF ENGINEERING
Department of Genetics and Bioengineering
GBE 440 | Course Introduction and Application Information
Course Name |
Gene Therapy
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
GBE 440
|
Fall/Spring
|
3
|
0
|
3
|
5
|
Prerequisites |
None
|
|||||
Course Language |
English
|
|||||
Course Type |
Elective
|
|||||
Course Level |
First Cycle
|
|||||
Mode of Delivery | - | |||||
Teaching Methods and Techniques of the Course | DiscussionGroup WorkQ&ALecture / Presentation | |||||
Course Coordinator | ||||||
Course Lecturer(s) | ||||||
Assistant(s) | - |
Course Objectives | The objective of this course is to introduce students the viral and nonviral gene transfer techniques and the molecular basis of these techniques. In this course, recent gene therapy applications in hereditary and acquired diseases will be explained and the importance of gene therapy as a therapeutic strategy will be discussed. |
Learning Outcomes |
The students who succeeded in this course;
|
Course Description | This course covers the description of fundamentals of gene therapy, viral and non-viral gene delivery techniques, and use of gene therapy as a treatment strategy. |
|
Core Courses | |
Major Area Courses |
X
|
|
Supportive Courses | ||
Media and Management Skills Courses | ||
Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
Week | Subjects | Related Preparation |
1 | Introduction to gene therapy | A Handbook of Gene and Cell Therapy - Chapter 1 |
2 | Non-viral Vectors for Gene Therapy | A Handbook of Gene and Cell Therapy - Chapter 2 |
3 | Viral Vectors for Gene Therapy-1 | A Handbook of Gene and Cell Therapy - Chapter 3 |
4 | Viral Vectors for Gene Therapy-2 | A Handbook of Gene and Cell Therapy - Chapter 3 |
5 | Barriers to Gene Delivery | A Handbook of Gene and Cell Therapy - Chapter 4 |
6 | Stem Cells and Tissue Regeneration-1 | A Handbook of Gene and Cell Therapy - Chapter 5 |
7 | Midterm Exam | |
8 | Stem Cells and Tissue Regeneration-2 | A Handbook of Gene and Cell Therapy - Chapter 5 |
9 | Gene Therapy Strategies: Gene Augmentation | A Handbook of Gene and Cell Therapy - Chapter 6 |
10 | Gene Therapy Strategies: Gene Silencing | A Handbook of Gene and Cell Therapy - Chapter 7 |
11 | Gene Editing | A Handbook of Gene and Cell Therapy - Chapter 8 |
12 | Gene Therapy Applications: Preclinical Studies and Clinical Trials | A Handbook of Gene and Cell Therapy - Chapter 9 |
13 | Gene Therapy for Cancer | An Introduction to Molecular Medicine and Gene Therapy, Chapter 6-7 |
14 | Gene Therapy for Eye Conditions and Cardiovascular Diseases (CVDs) | A Handbook of Gene and Cell Therapy - Chapter 9 |
15 | Gene Therapy for Neurodegenerative Diseases | A Handbook of Gene and Cell Therapy - Chapter 9 |
16 | Final exam |
Course Notes/Textbooks | An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina ISBNs: 0-471-39188-3 (Hardback); 0-471-22387-5 (Electronic) |
Suggested Readings/Materials | An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005 |
EVALUATION SYSTEM
Semester Activities | Number | Weigthing |
Participation | ||
Laboratory / Application | ||
Field Work | ||
Quizzes / Studio Critiques |
1
|
10
|
Portfolio | ||
Homework / Assignments |
1
|
20
|
Presentation / Jury |
1
|
20
|
Project | ||
Seminar / Workshop | ||
Oral Exams | ||
Midterm |
1
|
20
|
Final Exam |
1
|
30
|
Total |
Weighting of Semester Activities on the Final Grade |
4
|
70
|
Weighting of End-of-Semester Activities on the Final Grade |
1
|
30
|
Total |
ECTS / WORKLOAD TABLE
Semester Activities | Number | Duration (Hours) | Workload |
---|---|---|---|
Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
Study Hours Out of Class |
16
|
2
|
32
|
Field Work |
0
|
||
Quizzes / Studio Critiques |
1
|
5
|
5
|
Portfolio |
0
|
||
Homework / Assignments |
1
|
10
|
10
|
Presentation / Jury |
1
|
15
|
15
|
Project |
0
|
||
Seminar / Workshop |
0
|
||
Oral Exam |
0
|
||
Midterms |
1
|
20
|
20
|
Final Exam |
1
|
20
|
20
|
Total |
150
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
1
|
2
|
3
|
4
|
5
|
||
1 | To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems. |
X | ||||
2 | To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose. |
|||||
3 | To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose. |
|||||
4 | To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively. |
|||||
5 | To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics. |
|||||
6 | To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually. |
X | ||||
7 | To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions. |
|||||
8 | To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions. |
|||||
9 | To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications. |
X | ||||
10 | To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development. |
|||||
11 | To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language. |
|||||
12 | To be able to speak a second foreign language at a medium level of fluency efficiently. |
|||||
13 | To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering. |
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
NEWS |ALL NEWS
Elderly’s quality of life will increase
4 scientists from Izmir University of Economics (IUE) have begun work on developing a drug aimed at treating osteoarthritis, a disease mostly
Germany chose Ezgi
Ezgi Kaya, who graduated from Izmir University of Economics (IUE) Department of Genetics and Bioengineering this year, was accepted to the world-famous
Geneticists’ success in ‘Germany’
Nine newly graduated students from Izmir University of Economics (IUE) Department of Genetics and Bioengineering achieved great success by being accepted to
'Sustainable energy' ideas from students
Izmir University of Economics (IUE) organized a workshop on biohydrogen, which is used in many fields from industry to transportation and stands
Discovery in thermal spring
Asst. Prof. Dr. Mine Güngörmüşler from Izmir University of Economics (IUE), Department of Genetics and Bioengineering, and two graduate students examined the
Arda ranked among 7 people in the world
Arda Kıpçak, who graduated from Department of Genetics and Bioengineering, Izmir University of Economics (IUE) this year, was accepted to the world-renowned
'Smart cabinet' against the virus
Assoc. Prof. Dr. Osman Doluca and his 4 students from Izmir University of Economics (IUE) developed a 'PCR cabinet' that allows samples