FACULTY OF ENGINEERING

Department of Genetics and Bioengineering

GBE 440 | Course Introduction and Application Information

Course Name
Gene Therapy
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
GBE 440
Fall/Spring
3
0
3
5

Prerequisites
None
Course Language
English
Course Type
Elective
Course Level
First Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course Discussion
Group Work
Q&A
Lecture / Presentation
Course Coordinator
Course Lecturer(s)
Assistant(s) -
Course Objectives The objective of this course is to introduce students the viral and nonviral gene transfer techniques and the molecular basis of these techniques. In this course, recent gene therapy applications in hereditary and acquired diseases will be explained and the importance of gene therapy as a therapeutic strategy will be discussed.
Learning Outcomes The students who succeeded in this course;
  • Describe molecular principles of gene therapy approaches
  • Describe the viral and non-viral gene transfer techniques
  • Model viral structures that are used as vectors in gene therapy, write a report and present their model
  • Discuss ethical issues in gene therapy.
Course Description This course covers the description of fundamentals of gene therapy, viral and non-viral gene delivery techniques, and use of gene therapy as a treatment strategy.

 



Course Category

Core Courses
Major Area Courses
X
Supportive Courses
Media and Management Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Related Preparation
1 Introduction to gene therapy A Handbook of Gene and Cell Therapy - Chapter 1
2 Non-viral Vectors for Gene Therapy A Handbook of Gene and Cell Therapy - Chapter 2
3 Viral Vectors for Gene Therapy-1 A Handbook of Gene and Cell Therapy - Chapter 3
4 Viral Vectors for Gene Therapy-2 A Handbook of Gene and Cell Therapy - Chapter 3
5 Barriers to Gene Delivery A Handbook of Gene and Cell Therapy - Chapter 4
6 Stem Cells and Tissue Regeneration-1 A Handbook of Gene and Cell Therapy - Chapter 5
7 Midterm Exam
8 Stem Cells and Tissue Regeneration-2 A Handbook of Gene and Cell Therapy - Chapter 5
9 Gene Therapy Strategies: Gene Augmentation A Handbook of Gene and Cell Therapy - Chapter 6
10 Gene Therapy Strategies: Gene Silencing A Handbook of Gene and Cell Therapy - Chapter 7
11 Gene Editing A Handbook of Gene and Cell Therapy - Chapter 8
12 Gene Therapy Applications: Preclinical Studies and Clinical Trials A Handbook of Gene and Cell Therapy - Chapter 9
13 Gene Therapy for Cancer An Introduction to Molecular Medicine and Gene Therapy, Chapter 6-7
14 Gene Therapy for Eye Conditions and Cardiovascular Diseases (CVDs) A Handbook of Gene and Cell Therapy - Chapter 9
15 Gene Therapy for Neurodegenerative Diseases A Handbook of Gene and Cell Therapy - Chapter 9
16 Final exam

 

Course Notes/Textbooks

An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina

ISBNs: 0-471-39188-3 (Hardback); 0-471-22387-5 (Electronic)

Suggested Readings/Materials

An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
1
10
Portfolio
Homework / Assignments
1
20
Presentation / Jury
1
20
Project
Seminar / Workshop
Oral Exams
Midterm
1
20
Final Exam
1
30
Total

Weighting of Semester Activities on the Final Grade
4
70
Weighting of End-of-Semester Activities on the Final Grade
1
30
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Theoretical Course Hours
(Including exam week: 16 x total hours)
16
3
48
Laboratory / Application Hours
(Including exam week: '.16.' x total hours)
16
0
Study Hours Out of Class
16
2
32
Field Work
0
Quizzes / Studio Critiques
1
5
5
Portfolio
0
Homework / Assignments
1
10
10
Presentation / Jury
1
15
15
Project
0
Seminar / Workshop
0
Oral Exam
0
Midterms
1
20
20
Final Exam
1
20
20
    Total
150

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems.

X
2

To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose.

3

To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose.

4

To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively.

5

To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics.

6

To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually.

X
7

To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions.

8

To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions.

9

To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications.

X
10

To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development.

11

To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language.

12

To be able to speak a second foreign language at a medium level of fluency efficiently.

13

To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering.

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest

 


NEWS |ALL NEWS

Izmir University of Economics
is an establishment of
izto logo
Izmir Chamber of Commerce Health and Education Foundation.
ieu logo

Sakarya Street No:156
35330 Balçova - İzmir / Turkey

kampus izmir

Follow Us

İEU © All rights reserved.