FACULTY OF ENGINEERING

Department of Genetics and Bioengineering

MED 310 | Course Introduction and Application Information

Course Name
Current Topics in Immunology and Cancer
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
MED 310
Fall/Spring
3
0
3
5

Prerequisites
None
Course Language
English
Course Type
Elective
Course Level
First Cycle
Mode of Delivery -
Teaching Methods and Techniques of the Course Discussion
Group Work
Jury
Lecture / Presentation
Course Coordinator
Course Lecturer(s)
Assistant(s) -
Course Objectives This course aims to inform students about the latest topics in immunology by focusing on cancer.
Learning Outcomes The students who succeeded in this course;
  • 1. Define the concepts and terms about immunology and cancer.
  • 2. Describe the cells and tissues of the immune system with their functions.
  • 3.Explain antigen presentation mechanisms associated with cancer.
  • 4.Explain natural, acquired and mucosal immunity.
  • 5.Explain immunology of transplantation, immune tolerance, autoimmunity and immune regulation concepts and relation to disorders.
  • 6. Describe “Tumor Antigens” and “Tumor Associated Antigens”
  • 7. Explain examples of cancer-specific immune responses and how tumors avoid these responses.
  • 8. Describe approaches for using immune responses for cancer treatment.
Course Description This course begins with a general introduction to the mechanism of antigen delivery, which is a summary of the innate and adaptive immune system, which aims to cover the functioning of the immune system cells and tissues and then the basic mechanisms of the immune system as a whole. The course will focus on the main mechanisms of tumor immune response and its therapy.

 



Course Category

Core Courses
Major Area Courses
Supportive Courses
Media and Management Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Related Preparation
1 Introduction to the Immune system: Cells and Tissues of the Immune System Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 1, 1-11 Chapter 2, 13-41
2 Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 6, 123-150
3 Innate Immune System Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 4, 63-102
4 Activation of T lymphocytes, Differentiation and Function of CD4 and CD8 T Cells Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 9, 217-232 Chapter 10, 233-250 Chapter 11, 251-259
5 B Cell Activation and Antibody production Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 12, 261-285
6 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 14, 313-336
7 Transplantation Immunology Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 17, 389-413
8 Immune Tolerance and Autoimmunity Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 15, 337-363
9 Immune Regulation Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 9 and 15 p 211-213, 315-339
10 Tumor Antigens Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
11 Tumor Immune Responses Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
12 Evasion of Immune Responses by Tumors Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
13 Immunotherapy for Tumors I: Passive Immunotherapy and Adoptive T Cell Therapy Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
14 Immunotherapy for Tumors II: Immune Checkpoint Blockade and Tumor Antigen Vaccination Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
15 Semester Review
16 Final Exam

 

Course Notes/Textbooks

Cellular and Molecular Immunology 10th Ed.  Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD

 

Access through www.clinicalkey.com

Suggested Readings/Materials

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
1
10
Laboratory / Application
Field Work
Quizzes / Studio Critiques
Portfolio
Homework / Assignments
1
20
Presentation / Jury
1
30
Project
Seminar / Workshop
Oral Exams
Midterm
Final Exam
1
40
Total

Weighting of Semester Activities on the Final Grade
3
60
Weighting of End-of-Semester Activities on the Final Grade
1
40
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Theoretical Course Hours
(Including exam week: 16 x total hours)
16
3
48
Laboratory / Application Hours
(Including exam week: '.16.' x total hours)
16
0
Study Hours Out of Class
14
2
28
Field Work
0
Quizzes / Studio Critiques
0
Portfolio
0
Homework / Assignments
1
15
15
Presentation / Jury
1
25
25
Project
0
Seminar / Workshop
0
Oral Exam
0
Midterms
0
Final Exam
1
24
24
    Total
140

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems.

2

To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose.

3

To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose.

4

To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively.

5

To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics.

6

To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually.

7

To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions.

8

To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions.

9

To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications.

10

To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development.

11

To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language.

12

To be able to speak a second foreign language at a medium level of fluency efficiently.

13

To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering.

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest

 


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