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      Department of Genetics and Bioengineering

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      MED 310 | Course Introduction and Application Information

      Course Name
      Current Topics in Immunology and Cancer
      Code
      Semester
      Theory
      (hour/week)
      Application/Lab
      (hour/week)
      Local Credits
      ECTS
      MED 310
      Fall/Spring
      3
      0
      3
      5

      Prerequisites
      None
      Course Language
      English
      Course Type
      Elective
      Course Level
      First Cycle
      Mode of Delivery -
      Teaching Methods and Techniques of the Course Discussion
      Group Work
      Jury
      Lecture / Presentation
      National Occupation Classification -
      Course Coordinator
      • Prof. Dr. Dicle GÜÇ
      Course Lecturer(s)
      • Prof. Dr. Dicle GÜÇ
      Assistant(s) -
      Course Objectives This course aims to inform students about the latest topics in immunology by focusing on cancer.
      Learning Outcomes
      #
      Content
      PC Sub
      * Contribution Level
      1
      2
      3
      4
      5
      11. Define the concepts and terms about immunology and cancer.
      22. Describe the cells and tissues of the immune system with their functions.
      33.Explain antigen presentation mechanisms associated with cancer.
      44.Explain natural, acquired and mucosal immunity.
      55.Explain immunology of transplantation, immune tolerance, autoimmunity and immune regulation concepts and relation to disorders.
      66. Describe “Tumor Antigens” and “Tumor Associated Antigens”
      77. Explain examples of cancer-specific immune responses and how tumors avoid these responses.
      88. Describe approaches for using immune responses for cancer treatment.
      Course Description This course begins with a general introduction to the mechanism of antigen delivery, which is a summary of the innate and adaptive immune system, which aims to cover the functioning of the immune system cells and tissues and then the basic mechanisms of the immune system as a whole. The course will focus on the main mechanisms of tumor immune response and its therapy.
      Related Sustainable Development Goals

       



      Course Category

      Core Courses
      Major Area Courses
      Supportive Courses
      Media and Management Skills Courses
      Transferable Skill Courses

       

      WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

      Week Subjects Related Preparation Learning Outcome
      1 Introduction to the Immune system: Cells and Tissues of the Immune System Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 1, 1-11 Chapter 2, 13-41
      2 Antigen Presentation to T Lymphocytes and the Function of Major Histocompatibility Complex Molecules Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 6, 123-150
      3 Innate Immune System Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 4, 63-102
      4 Activation of T lymphocytes, Differentiation and Function of CD4 and CD8 T Cells Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 9, 217-232 Chapter 10, 233-250 Chapter 11, 251-259
      5 B Cell Activation and Antibody production Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 12, 261-285
      6 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 14, 313-336
      7 Transplantation Immunology Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 17, 389-413
      8 Immune Tolerance and Autoimmunity Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 15, 337-363
      9 Immune Regulation Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 9 and 15 p 211-213, 315-339
      10 Tumor Antigens Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
      11 Tumor Immune Responses Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
      12 Evasion of Immune Responses by Tumors Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
      13 Immunotherapy for Tumors I: Passive Immunotherapy and Adoptive T Cell Therapy Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
      14 Immunotherapy for Tumors II: Immune Checkpoint Blockade and Tumor Antigen Vaccination Cellular and Molecular Immunology 10th Ed. Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD Chapter 18 Tumor Immunology 415-436 www.clinicalkey.com
      15 Semester Review
      16 Final Exam

       

      Course Notes/Textbooks

      Cellular and Molecular Immunology 10th Ed.  Abul K. Abbas MBBS, Andrew H. Lichtman MD, PhD and Shiv Pillai MBBS, PhD

       

      Access through www.clinicalkey.com

      Suggested Readings/Materials

       

      EVALUATION SYSTEM

      Semester Activities Number Weigthing LO 1 LO 2 LO 3 LO 4 LO 5 LO 6 LO 7 LO 8
      Participation
      1
      10
      Laboratory / Application
      Field Work
      Quizzes / Studio Critiques
      Portfolio
      Homework / Assignments
      1
      20
      Presentation / Jury
      1
      30
      Project
      Seminar / Workshop
      Oral Exams
      Midterm
      Final Exam
      1
      40
      Total

      Weighting of Semester Activities on the Final Grade
      3
      60
      Weighting of End-of-Semester Activities on the Final Grade
      1
      40
      Total

      ECTS / WORKLOAD TABLE

      Semester Activities Number Duration (Hours) Workload
      Theoretical Course Hours
      (Including exam week: 16 x total hours)
      16
      3
      48
      Laboratory / Application Hours
      (Including exam week: '.16.' x total hours)
      16
      0
      Study Hours Out of Class
      14
      2
      28
      Field Work
      0
      Quizzes / Studio Critiques
      0
      Portfolio
      0
      Homework / Assignments
      1
      15
      15
      Presentation / Jury
      1
      25
      25
      Project
      0
      Seminar / Workshop
      0
      Oral Exam
      0
      Midterms
      0
      Final Exam
      1
      24
      24
          Total
      140

       

      COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

      #
      PC Sub Program Competencies/Outcomes
      * Contribution Level
      1
      2
      3
      4
      5
      1

      To have adequate knowledge in Mathematics, Science and Genetics and Bioengineering; to be able to use theoretical and applied information in these areas on complex engineering problems.

      -
      -
      -
      -
      -
      2

      To be able to identify, define, formulate, and solve complex Genetics and Bioengineering problems; to be able to select and apply proper analysis and modeling methods for this purpose.

      -
      -
      -
      -
      -
      3

      To be able to design a complex system, process, device or product under realistic constraints and conditions, in such a way as to meet the requirements; to be able to apply modern design methods for this purpose.

      -
      -
      -
      -
      -
      4

      To be able to devise, select, and use modern techniques and tools needed for analysis and solution of complex problems in Genetics and Bioengineering applications; to be able to use information technologies effectively.

      -
      -
      -
      -
      -
      5

      To be able to design and conduct experiments, gather data, analyze and interpret results for investigating complex engineering problems or Genetics and Bioengineering research topics.

      -
      -
      -
      -
      -
      6

      To be able to work efficiently in Genetics and Bioengineering disciplinary and multi-disciplinary teams; to be able to work individually.

      -
      -
      -
      -
      -
      7

      To be able to communicate effectively in Turkish, both orally and in writing; to be able to author and comprehend written reports, to be able to prepare design and implementation reports, to present effectively, to be able to give and receive clear and comprehensible instructions.

      -
      -
      -
      -
      -
      8

      To have knowledge about global and social impact of Genetics and Bioengineering practices on health, environment, and safety; to have knowledge about contemporary issues as they pertain to engineering; to be aware of the legal ramifications of Genetics and Bioengineering solutions.

      -
      -
      -
      -
      -
      9

      To be aware of ethical behavior, professional and ethical responsibility; to have knowledge about standards utilized in Genetics and Bioengineering applications.

      -
      -
      -
      -
      -
      10

      To have knowledge about industrial practices such as project management, risk management, and change management; to have awareness of entrepreneurship and innovation; to have knowledge about sustainable development.

      -
      -
      -
      -
      -
      11

      To be able to collect data in the area of Genetics and Bioengineering, and to be able to communicate with colleagues in a foreign language.

      -
      -
      -
      -
      -
      12

      To be able to speak a second foreign language at a medium level of fluency efficiently.

      -
      -
      -
      -
      -
      13

      To recognize the need for lifelong learning; to be able to access information, to be able to stay current with developments in science and technology; to be able to relate the knowledge accumulated throughout the human history to Genetics and Bioengineering.

      -
      -
      -
      -
      -

      *1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest


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