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Department of Genetics and Bioengineering
GBE 206 | Course Introduction and Application Information
| Course Name |
Genetics
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
GBE 206
|
FALL
|
2
|
2
|
3
|
5
|
| Prerequisites | None | |||||
| Course Language | English | |||||
| Course Type | Required (Core Course) | |||||
| Course Level | First Cycle | |||||
| Mode of Delivery | Face-To-Face | |||||
| Teaching Methods and Techniques of the Course |
Lecture / Presentation Q&A Problem solving |
|||||
| National Occupational Classification Code | - | |||||
| Course Coordinator |
|
|||||
| Course Lecturer(s) |
|
|||||
| Assistant(s) |
|
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| Course Objectives | The aim of this course is to teach the molecular structure and function of the genome by providing basic information about the effects of genetic variants on cells and populations. At the same time, the necessary methods to establish the relationship between phenotype and genotype and to determine pathological gene mechanisms are also taught. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Learning Outcomes |
The students who succeeded in this course;
|
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| Course Description | The mechanisms that control the expression of genetic information and the phenomena that carry out the transfer of this information at both the cellular and population levels will be covered in this course. Detailed information will be given about the events that occur during the reading of genetic information and the epigenetic and genetic parameters necessary for the disclosure of this information, and how the deterioration in these causes diseases will be explained with examples. In addition, the theoretical background of the basic techniques required to measure the mentioned parameters will be discussed and ethical/legal aspects will be discussed. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Related Sustainable Development Goals |
-
|
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|
|
Core Courses |
X
|
| Major Area Courses |
|
|
| Supportive Courses |
|
|
| Media and Managment Skills Courses |
|
|
| Transferable Skill Courses |
|
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Required Materials | Learning Outcome |
| 1 | Contents of the genome | Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-9. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012. | e42b5baf |
| 2 | Gene circuit elements | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012. | e42b5baf |
| 3 | Chromosome architecture | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-2. • Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739. | e42b5baf |
| 4 | Classical gene control mechanisms | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases, Decker and Hinton, Annual Reviews, 2013. | a1a3fb8b |
| 5 | Epigenetic gene control mechanisms: Histone modifications | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. | a1a3fb8b |
| 6 | Epigenetic gene control mechanisms: Histone modifications | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016. | a1a3fb8b |
| 7 | Epigenetic gene control mechanisms: DNA methylation | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Principles of DNA methylation and their implications for biology and medicine, Dor and Cedar, Lancet, 2018. | 5d2ae953 |
| 8 | Review and Midterm Exam | - | |
| 9 | Post-transcriptional gene control mechanisms | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Molecular mechanisms of RNA interference, Wilson and Doudna. Annual Reviews, vol. 42:217-239 | 5d2ae953 |
| 10 | Human genetic variation | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-11. | 29ef1d64 |
| 11 | Chromosomal abnormalities and structural variants | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-15. | 9277c5d1 |
| 12 | Human population genetics | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-12. | c89a4edf |
| 13 | Phenotype and genotype correlation | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-16. | 5d2ae953 |
| 14 | Mapping and identification of disease-causing genes | • Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-17. | c89a4edf |
| 15 | Semester Review | - | |
| 16 | Final Exam | - |
| Course Notes/Textbooks | Human Molecular Genetics. Strachan and Read. Garland Science. 2018. ISBN: 0815345895 |
| Suggested Readings/Materials |
•Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739. Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım PhD Thesis Imperial College London 2012. Transcription Regulation at the Core: Similarities Among Bacterial Archaeal and Eukaryotic RNA Polymerases. Decker and Hinton. Annual Reviews. 2013. Lateral Thinking: How Histone Modifications Regulate Gene Expression. Lawrence et al. Trends in Genetics. 2016. Principles of DNA methylation and their implications for biology and medicine. Dor and Cedar. Lancet. 2018. Molecular mechanisms of RNA interference. Wilson and Doudna. Annual Reviews vol. 42:217-239 |
EVALUATION SYSTEM
| Semester Activities | Number | Weighting | LO1 | LO2 | LO3 | LO4 | LO5 | LO6 |
| Homework / Assignments | 3 | 30 | X | X | X | X | ||
| Midterm | 1 | 30 | X | X | X | X | ||
| Final Exam | 1 | 40 | X | X | X | X | ||
| Total | 5 | 100 |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Participation | - | - | - |
| Theoretical Course Hours | 16 | 2 | 32 |
| Laboratory / Application Hours | 16 | 2 | 32 |
| Study Hours Out of Class | 14 | 2 | 28 |
| Field Work | - | - | - |
| Quizzes / Studio Critiques | 3 | 5 | 15 |
| Portfolio | - | - | - |
| Homework / Assignments | 1 | 5 | 5 |
| Presentation / Jury | - | - | - |
| Project | - | - | - |
| Seminar / Workshop | - | - | - |
| Oral Exams | - | - | - |
| Midterms | 1 | 18 | 18 |
| Final Exam | 1 | 20 | 20 |
| Total | 150 |
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
| # | PC Sub | Program Competencies/Outcomes | * Contribution Level | ||||
| 1 | 2 | 3 | 4 | 5 | |||
| No program competency data found. | |||||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest
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