Genetik ve Biyomühendislik

GBE 206 | Ders Tanıtım Bilgileri

Dersin Adı

Genetics

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 206	FALL	2	2	3	5

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	Zorunlu
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face-To-Face
Dersin Öğretim Yöntem ve Teknikleri	Lecture / Presentation Q&A Problem solving
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Doç. Dr. Cihangir Yandım
Öğretim Eleman(lar)ı	Doç. Dr. Cihangir Yandım
Yardımcı(ları)	Araş. Gör. Sıla Naz Köse

Dersin Amacı

The aim of this course is to teach the molecular structure and function of the genome by providing basic information about the effects of genetic variants on cells and populations. At the same time, the necessary methods to establish the relationship between phenotype and genotype and to determine pathological gene mechanisms are also taught.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Explain the detailed content of the genome and its multi-layered control systems	1.2			X
LO2	Define histone modification, DNA methylation, RNA interference and methods to recognize them	2		X
LO3	Give examples of variations in the genome	1.5			X
LO4	Estimate allele frequencies in a population by calculating them with different parameters	5.3	X
LO5	Determine methods that identify pathological genes and interpret the results	5.1		X
LO6	Discuss the ethical and legal aspects of genetic identification	7.1	X

Ders Tanımı

The mechanisms that control the expression of genetic information and the phenomena that carry out the transfer of this information at both the cellular and population levels will be covered in this course. Detailed information will be given about the events that occur during the reading of genetic information and the epigenetic and genetic parameters necessary for the disclosure of this information, and how the deterioration in these causes diseases will be explained with examples. In addition, the theoretical background of the basic techniques required to measure the mentioned parameters will be discussed and ethical/legal aspects will be discussed.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders	X
	Uzmanlık/Alan Dersleri
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Contents of the genome	Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-9. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012.	e42b5baf
2	Gene circuit elements	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım, PhD Thesis, Imperial College London, 2012.	e42b5baf
3	Chromosome architecture	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-2. • Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739.	e42b5baf
4	Classical gene control mechanisms	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-1. • Transcription Regulation at the Core: Similarities Among Bacterial, Archaeal, and Eukaryotic RNA Polymerases, Decker and Hinton, Annual Reviews, 2013.	a1a3fb8b
5	Epigenetic gene control mechanisms: Histone modifications	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10.	a1a3fb8b
6	Epigenetic gene control mechanisms: Histone modifications	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Lateral Thinking: How Histone Modifications Regulate Gene Expression, Lawrence et al., Trends in Genetics, 2016.	a1a3fb8b
7	Epigenetic gene control mechanisms: DNA methylation	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Principles of DNA methylation and their implications for biology and medicine, Dor and Cedar, Lancet, 2018.	5d2ae953
8	Review and Midterm Exam		-
9	Post-transcriptional gene control mechanisms	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-10. • Molecular mechanisms of RNA interference, Wilson and Doudna. Annual Reviews, vol. 42:217-239	5d2ae953
10	Human genetic variation	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-11.	29ef1d64
11	Chromosomal abnormalities and structural variants	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-15.	9277c5d1
12	Human population genetics	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-12.	c89a4edf
13	Phenotype and genotype correlation	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-16.	5d2ae953
14	Mapping and identification of disease-causing genes	• Human Molecular Genetics. Strachan and Read, Garland Science, 2018. Chapter-17.	c89a4edf
15	Semester Review		-
16	Final Exam		-

Ders Kitabı

Human Molecular Genetics. Strachan and Read. Garland Science. 2018. ISBN: 0815345895

Önerilen Okumalar/Materyaller

•Chromosome Architecture and Genome Organization. G Bernardi. PLoS One. 2015; 10(11): e0143739.
Heterochromatin effects in Friedreich's ataxia and sexual dimorphism. C. Yandım
PhD Thesis
Imperial College London
2012.
Transcription Regulation at the Core: Similarities Among Bacterial Archaeal and Eukaryotic RNA Polymerases. Decker and Hinton. Annual Reviews. 2013.
Lateral Thinking: How Histone Modifications Regulate Gene Expression. Lawrence et al. Trends in Genetics. 2016.
Principles of DNA methylation and their implications for biology and medicine. Dor and Cedar. Lancet. 2018. Molecular mechanisms of RNA interference. Wilson and Doudna. Annual Reviews
vol. 42:217-239

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5	LO6
Ödev	3	30		X	X		X	X
Ara Sınav	1	30	X	X		X		X
Final Sınavı	1	40	X		X	X	X
Toplam	5	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	2	32
Laboratuvar / Uygulama Ders Saati	16	2	32
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	3	5	15
Portfolyo	-	-	-
Ödev	1	5	5
Sunum / Jüri Önünde Sunum	-	-	-
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	18	18
Final Sınavı	1	20	20
		Toplam	150

DERSİN ÖĞRENME ÇIKTILARININ PROGRAM YETERLİLİKLERİ İLE İLİŞKİSİ

#	PC Alt	Program Yeterlilikleri / Çıktıları	* Katkı Düzeyi
#	PC Alt	Program Yeterlilikleri / Çıktıları	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science			LO1
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics			LO3
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.			LO2
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems		LO5
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results	LO4
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility	LO6
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.