Genetik ve Biyomühendislik

GBE 310 | Ders Tanıtım Bilgileri

Dersin Adı

Stem Cells

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 310	SPRING	3	0	3	5

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face-To-Face
Dersin Öğretim Yöntem ve Teknikleri	Discussion Group Work Q&A Lecture / Presentation
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Öğretim Eleman(lar)ı	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Yardımcı(ları)	-

Dersin Amacı

The aim of this course is to learn the basics of stem cell biology, to gain information about the clinical applications of stem cells, and to discuss the role of stem cells in drug discovery.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Define embryonic, hematopoietic and induced multipotential stem cells	1.5		X
LO2	Explain the use of stem cells in cell therapy	1.5		X
LO3	Describe the use of stem cells in tissue engineering and drug discovery	1.5		X
LO4	Design a project to develop stem cell-mediated therapy for the treatment of a disease	3.2			X
LO5	Critically discuss current literature and research articles on stem cells	3.2			X

Ders Tanımı

Embryonic stem cells, Blood stem cells, Adult stem cells, Tissue engineering, Cell therapy, Drug discovery

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Stem Cells, Properties, Types and Stem Cell Niche	Stem Cell Engineering: Principles and Applications	LO1
2	Human Embryonic and Induced Multipotential Stem Cells	Stem Cell Engineering: Principles and Applications	LO1
3	Genetic Modification of Human Embryonic and Induced Multipotential Stem Cells	Stem Cell Engineering: Principles and Applications Chapter 7	LO1
4	Hematopoietic Stem Cells - Therapeutic Potential of Embryonic Stem Cell-Derived Blood Cells	Stem Cell Engineering: Principles and Applications Chapter 6	LO2
5	Mesenchymal Stem Cells	Stem Cell Engineering: Principles and Applications Chapter 7	LO2
6	Potential of Selectively Cultured Adult Stem Cells Reinserted into Tissues	Stem Cell Engineering: Principles and Applications Chapter 4	LO2
7	Immune Barriers in Cell Therapy with Embryonic Origin Allogeneic Stem Cells	Stem Cell Engineering: Principles and Applications Chapter 8	LO2
8	Midterm Exam		-
9	Tissue Engineering	Stem Cell Engineering: Principles and Applications Chapter 12	LO3
10	Endothelial Progenitor Cells for Vascular Repair	Stem Cell Engineering: Principles and Applications Chapter 13	LO3
11	Biosynthetic Encapsulation Systems for Organ Engineering-A Look at Diabetes	Stem Cell Engineering: Principles and Applications Chapter 16	LO3
12	Adult Stem Cells in Drug Discovery	Stem Cell Engineering: Principles and Applications Chapter 21	LO4
13	Embryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing	Stem Cell Engineering: Principles and Applications Chapter 22	LO4
14	Article Presentations		-
15	Semester Review		-
16	Final Exam		-

Ders Kitabı	Stem Cell Engineering: Principles and Applications. Editors Artmann & Minger and Hescheler. Springer (2011)
Önerilen Okumalar/Materyaller	Essentials of Stem Cell Biology – Robert Lanza & Anthony Atala - Elsevier Principles of Stem Cell Biology and Cancer – Future Applications and Therapeutic – Editors: Tarik Regad & Thomas J Sayers & Robert Rees – Wiley Blackwell Stem Cell Biology – Edited by Daniel R Marshak Richard L Gardner & David Gottlieb – Cold Spring Harbor Laboratory Press

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5
Küçük Sınav / Stüdyo Kritiği	1	5	X
Ödev	1	5	X	X
Sunum / Jüri Önünde Sunum	1	20				X	X
Proje	1	15				X	X
Ara Sınav	1	25	X	X	X
Final Sınavı	1	30	X	X	X	X	X
Toplam	6	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	3	48
Laboratuvar / Uygulama Ders Saati	-	-	-
Sınıf Dışı Ders Çalışması	12	1	12
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	1	5	5
Portfolyo	-	-	-
Ödev	1	5	5
Sunum / Jüri Önünde Sunum	1	10	10
Proje	1	20	20
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	20	20
Final Sınavı	1	30	30
		Toplam	150

DERSİN ÖĞRENME ÇIKTILARININ PROGRAM YETERLİLİKLERİ İLE İLİŞKİSİ

#	PC Alt	Program Yeterlilikleri / Çıktıları	* Katkı Düzeyi
#	PC Alt	Program Yeterlilikleri / Çıktıları	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics		LO1 LO2 LO3
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions			LO4 LO5
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.