Genetik ve Biyomühendislik

GBE 360 | Ders Tanıtım Bilgileri

Dersin Adı

Cell Signaling

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 360	SPRING	3	0	3	5

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	ELECTIVE_COURSE
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face-To-Face
Dersin Öğretim Yöntem ve Teknikleri	Discussion Group Work Q&A Lecture / Presentation
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Öğretim Eleman(lar)ı	Dr. Öğr. Üyesi Yağmur Kiraz Durmaz
Yardımcı(ları)	-

Dersin Amacı

This course aims to provide students with information about the mechanisms of intracellular signaling and to address the importance of signaling in physiology and diseases.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Describe signal transduction and the biological properties of this system	1.5		X
LO2	Understand and compare the diversity of signaling mechanisms: receptors, ligands, second messengers, adapters, post-translational modifications	1.5		X
LO3	Explain the relationship between signal transduction and development, diseases and health.	1.5		X
LO4	Critically discuss the literature on signal transduction	5.1		X
LO5	Discuss existing paradigms of signal transduction, ask new questions, and hypothesize	5.1		X

Ders Tanımı

Fundamental aspects of cell signaling. Characterization of intracellular signaling structures: signaling molecules, receptors, second messengers, effectors, signaling complexes. Classification and properties of membrane receptors. Intracellular/nuclear receptors. Major signaling pathways.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders
	Uzmanlık/Alan Dersleri	X
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Signal Transduction Mechanisms: Signals and Sensors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-1,2	10df02e4
2	Signal Transduction Mechanisms: Secondary Messengers	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 1-3	10df02e4
3	Signaling Pathways: G-Protein Coupled Receptors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
4	Signaling Pathways: Receptor and Nonreceptor Tyrosine Kinases	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
5	Signaling Pathways: Serine/Threonine Kinase Coupled Receptors	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
6	Signaling Pathways: Mitogen-Activated Protein Kinases	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
7	Signaling Pathways: Phosphatidylinositol-Mediated Signaling	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 2	4a9d0b68
8	Midterm Exam		-
9	Growth Factor Signals	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
10	Cell Death Signals	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
11	DNA Damage Response	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
12	Heat Shock and ER Stress Response	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	34183f2e
13	Metabolism and Signaling	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	eaa26005
14	Signal Transduction in Health and Disease	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Chapter 3	d04b24fc
15	Semester Review		-
16	Final Exam		-

Ders Kitabı	Signal Transduction. 2014. Cold Spring Harbor Laboratory Press. Lewis Cantley & Tony Thunter & Richard Sever and Jeremy Thorner.
Önerilen Okumalar/Materyaller	Cellular Signaling Processing. 2008. Garland Science. Friedrich Marks & Ursula Klingmuller and Karin Muller-Decker Biochemistry of Signal Transduction and Regulation. 2014. Wiley-VCH. Gerhard Krauss Signal Transduction. 2015. Academic Press. Bastien D. Gomperts & Ijsbrand M. Kramer and Peter E. R. Tatham.

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5
Ödev	1	20	X	X	X
Sunum / Jüri Önünde Sunum	1	20			X	X	X
Ara Sınav	1	30	X	X	X
Final Sınavı	1	30	X	X	X	X	X
Toplam	4	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	3	48
Laboratuvar / Uygulama Ders Saati	-	-	-
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	-	-	-
Portfolyo	-	-	-
Ödev	1	12	12
Sunum / Jüri Önünde Sunum	1	20	20
Proje	-	-	-
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	17	17
Final Sınavı	1	25	25
		Toplam	150

DERSİN ÖĞRENME ÇIKTILARININ PROGRAM YETERLİLİKLERİ İLE İLİŞKİSİ

#	PC Alt	Program Yeterlilikleri / Çıktıları	* Katkı Düzeyi
#	PC Alt	Program Yeterlilikleri / Çıktıları	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics		LO1 LO2 LO3
	6	The ability to apply this knowledge to solve complex engineering problems
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems		LO4 LO5
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.