Genetik ve Biyomühendislik

GBE 411 | Ders Tanıtım Bilgileri

Dersin Adı

Design and Analysis in Bioengineering

Kodu	Yarıyıl	Teori (saat/hafta)	Uygulama/Lab (saat/hafta)	Yerel Kredi	AKTS
GBE 411	SPRING	2	2	3	6

Ön-Koşul(lar)	Yok
Dersin Dili	English
Dersin Türü	Zorunlu
Dersin Düzeyi	Lisans
Dersin Veriliş Şekli	Face to Face
Dersin Öğretim Yöntem ve Teknikleri	Group Work Problem Solving Lecture / Presentation Application: Interactive Learning
Ulusal Meslek Sınıflandırma Kodu	-
Dersin Koordinatörü	Doç. Dr. Mine Güngörmüşler
Öğretim Eleman(lar)ı	Dr. Öğr. Üyesi Gülizar Çalışkan Doç. Dr. Mine Güngörmüşler Dr. Öğr. Üyesi Işınay Ebru Yüzay Dr. Öğr. Üyesi Fatma Pınar Gördesli Duatepe
Yardımcı(ları)	-

Dersin Amacı

The aim of this course is to convey theoretical and practical concepts related to the interpretation and application of bioengineering principles and knowledge, acquired throughout the educational process, within the context of process design.

Öğrenme Çıktıları

Bu dersi başarıyla tamamlayabilen öğrenciler;

Ad	Açıklama	PC Alt	* Katkı Düzeyi
Ad	Açıklama	PC Alt	1	2	3	4	5
LO1	Identify design principles for a designated bioprocess.	3.1		X
LO2	Collect data on production processes.	1.5	X
LO3	Explain the process from raw material input to product output for a designated bioprocess.	4	X
LO4	Describe the selection of suitable equipment and bioreactor design for a designated bioprocess.	1.6		X
LO5	Discuss strategies for the design and analysis of separation and purification processes in a designated bioprocess.	3.2			X
LO6	Assess the feasibility of a bioprocess design for industrial production.	2			X

Ders Tanımı

This course covers the identification of design principles and methods encountered in bioengineering, tracking development processes, reviewing relevant resources, selecting and evaluating potential raw materials and productions, determining and utilizing capacity, creating process design flow diagrams, mass and energy balances for the selected system, equipment and bioreactor design, designing the separation and purification process, and conducting feasibility studies.

Dersin İlişkili Olduğu Sürdürülebilir Kalkınma Amaçları

Dersin Kategorisi	Temel Ders	X
	Uzmanlık/Alan Dersleri
	Destek Dersleri
	İletişim ve Yönetim Becerileri Dersleri
	Aktarılabilir Beceri Dersleri

HAFTALIK KONULAR VE İLGİLİ ÖN HAZIRLIK ÇALIŞMALARI

Hafta	Konular	Ön Hazırlık	Öğrenme Çıktısı
1	Definition of the bioprocess and development processes	Interactive study and articles Chapter 1, Bioprocess Engineering Principles (2nd Edition)	LO1
2	Market research, determination of capacity and raw materials	Interactive study and articles Chapter 3, Bioprocess Engineering Principles (2nd Edition)	LO2
3	Creation of flow diagrams	Interactive study and articles Chapters 4 and 5, Bioprocess Engineering Principles (2nd Edition)	LO2
4	Mass and energy balances	Interactive study and articles Chapters 4 and 5, Bioprocess Engineering Principles (2nd Edition)	LO3
5	Identification of basic equipment	Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition)	LO3
6	Pretreatments	Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition)	LO3
7	Research on reaction and microbial kinetics	Interactive study and articles Chapter 2, Bioprocess Engineering Principles (2nd Edition)	LO4
8	Review and Midterm		-
9	Explanation of bioreactor types and selection specific to the process, bioreactor design	Interactive study and articles Chapter 14, Bioprocess Engineering Principles (2nd Edition)	LO4
10	Bioreactor design	Interactive study and articles Chapter 14, Bioprocess Engineering Principles (2nd Edition)	LO4
11	Equipment selection , determination of piping system, pump, valve, connectors	Interactive study and articles Chapter 11, Bioprocess Engineering Principles (2nd Edition)	LO4
12	Evaluation of separation and purification processes	Interactive study Singh & Herzer (2018), Adv Biochem Eng Biotechnol, 165:115–178	LO5
13	Design and analysis of the separation and purification process Feasibility analysis	Interactive study Singh & Herzer (2018), Adv Biochem Eng Biotechnol, 165:115–178; Pollock et al. (2017), Biotechnol Prog, 33(4): 854–866	LO6
14	Project presentations		-
15	Project presentations		-
16	General semester review		-

Ders Kitabı

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (6th edition). Rifai- Horvath- Wittwer. Elsevier 2018 ISBN: 978-0-323-35921-4 Computational Drug Discovery and Design. Springer Protocols- Humana Press- 2018. Gore and Jagtap. ISBN 978-1-4939-7755-0 Bioprocess Engineering Principles (2nd Edition)- Doran P- Academic Press- 2012. ISBN: 978-0122208515

Önerilen Okumalar/Materyaller

Experimental design methods for bioengineering applications. Gundogdu et al. Crit Rev Biotechnol. 2016;36(2):368-88. Model-assisted design of experiments as a concept for knowledge-based bioprocess development. Moller et al. Bioprocess Biosyst Eng. 2019 May;42(5):867-882. Downstream Processing Technologies/Capturing and Final Purification : Opportunities for Innovation Change and Improvement. A Review of Downstream Processing Developments in Protein Purification. Singh and Herzer. Adv Biochem Eng Biotechnol. 2018;165:115-178. Integrated continuous bioprocessing: Economic operational and environmental feasibility for clinical and commercial antibody manufacture. Pollock et al. Biotechnol Prog. 2017 ; 33(4): 854–866. Heller et al. Annu Rev Anal Chem (Palo Alto Calif). 2018; 12;11(1):79-100.

DEĞERLENDİRME ÖLÇÜTLERİ

Yarıyıl Aktiviteleri	Sayı	Katkı Payı %	LO1	LO2	LO3	LO4	LO5	LO6
Ödev	1	20	X	X
Sunum / Jüri Önünde Sunum	1	20				X	X	X
Proje	1	30			X	X	X	X
Ara Sınav	1	30	X	X	X
Toplam	4	100

AKTS / İŞ YÜKÜ TABLOSU

Yarıyıl Aktiviteleri	Sayı	Süre (Saat)	İş Yükü
Katılım	-	-	-
Teorik Ders Saati	16	2	32
Laboratuvar / Uygulama Ders Saati	16	2	32
Sınıf Dışı Ders Çalışması	14	2	28
Arazi Çalışması	-	-	-
Küçük Sınav / Stüdyo Kritiği	-	-	-
Portfolyo	-	-	-
Ödev	5	3	15
Sunum / Jüri Önünde Sunum	1	5	5
Proje	1	20	20
Seminer/Çalıştay	-	-	-
Sözlü Sınav	-	-	-
Ara Sınavlar	1	18	18
Final Sınavı	-	-	-
		Toplam	150

DERSİN ÖĞRENME ÇIKTILARININ PROGRAM YETERLİLİKLERİ İLE İLİŞKİSİ

#	PC Alt	Program Yeterlilikleri / Çıktıları	* Katkı Düzeyi
#	PC Alt	Program Yeterlilikleri / Çıktıları	1	2	3	4	5
1	Engineering Knowledge: Knowledge of mathematics, science, basic engineering, computation, and related engineering discipline-specific topics; the ability to apply this knowledge to solve complex engineering problems.
	1	Mathematics
	2	Science
	3	Basic Engineering
	4	Computation
	5	Related engineering discipline-specific topics	LO2
	6	The ability to apply this knowledge to solve complex engineering problems		LO4
2	Problem Analysis: Ability to identify, formulate and analyze complex engineering problems using basic knowledge of science, mathematics and engineering, and considering the UN Sustainable Development Goals relevant to the problem being addressed.				LO6
3	Engineering Design: The ability to devise creative solutions to complex engineering problems; the ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions.
	1	Ability to design creative solutions to complex engineering problems		LO1
	2	Ability to design complex systems, processes, devices or products to meet current and future needs, considering realistic constraints and conditions			LO5
4	Use of Techniques and Tools: Ability to select and use appropriate techniques, resources, and modern engineering and computing tools, including estimation and modeling, for the analysis and solution of complex engineering problems, while recognizing their limitations.		LO3
5	Research and Investigation: Ability to use research methods to investigate complex engineering problems, including literature research, designing and conducting experiments, collecting data, and analyzing and interpreting results.
	1	Literature research for the study of complex engineering problems
	2	Designing experiments
	3	Ability to use research methods, including conducting experiments, collecting data. analyzing and interpreting results
6	Global Impact of Engineering Practices: Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals; awareness of the legal implications of engineering solutions.
	1	Knowledge of the impacts of engineering practices on society, health and safety, economy, sustainability, and the environment, within the context of the UN Sustainable Development Goals
	2	Awareness of the legal implications of engineering solutions
7	Ethical Behavior: Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility; awareness of being impartial, without discrimination, and being inclusive of diversity.
	1	Acting in accordance with the principles of the engineering profession, knowledge about ethical responsibility ethical responsibility
	2	Awareness of being impartial and inclusive of diversity, without discriminating on any subject
8	Individual and Teamwork: Ability to work effectively, individually and as a team member or leader on interdisciplinary and multidisciplinary teams (face-to-face, remote or hybrid).
	1	Ability to work individually and within the discipline
	2	Ability to work effectively as a team member or leader in multidisciplinary teams (face-to-face, remote or hybrid)
9	Verbal and Written Communication: Taking into account the various differences of the target audience (such as education, language, profession) on technical issues.
	1	Ability to communicate verbally
	2	Ability to communicate effectively in writing
10	Project Management: Knowledge of business practices such as project management and economic feasibility analysis; awareness of entrepreneurship and innovation.
	1	Knowledge of business practices such as project management and economic feasibility analysis
	2	Awareness of entrepreneurship and innovation
11	Lifelong Learning: Lifelong learning skills that include being able to learn independently and continuously, adapting to new and developing technologies, and thinking questioningly about technological changes.